Wilfred Jaeger

North American Scientific, Inc. manufactures and markets medical devices for the radiation oncology community. It offers intensity modulated and image guided radiation therapy products and services, as well as brachytherapy seeds used in the treatment of prostate cancer. The company also offers iodine-based and palladium-based implantable brachytherapy seeds for the treatment of prostate cancer. It provides a line of brachytherapy seeds for use in the treatment of ocular melanoma and other solid tumor applications. The company manufactures other radio isotopic products used in various medical, environmental, research and industrial applications. North American Scientific was incorporated in 1990 and is headquartered in Chatsworth, CA.

Threshold Pharmaceuticals, Inc. engages in the development of therapeutics for treating tumors. It offers the Evofosfamide which designed as a prodrug that is activated under the extreme hypoxic conditions commonly found in tumors, but not typically in healthy tissues, and TH-3424 which is a small-molecule drug candidate for the treatment of liver, castrate resistant prostate cancer, T-cell acute lymphoblastic leukemias, and other cancers. The company was founded by Jeffrey W. Bird on October 17, 2001 and is headquartered in South San Francisco, CA

Sirtris Pharmaceuticals, Inc., a GSK company, is developing small molecule drugs that target the sirtuins, a family of seven enzymes associated with diseases of aging. Modulation of these enzymes offers the promise of drug discovery in multiple therapeutic areas. Sirtris was one of the pharmaceutical companies focused on the sirtuin platform and remains the innovative drug discovery. Preclinical research indicates that the sirtuins play important roles in pathways for multiple diseases of aging, including Type 2 Diabetes, as well as neurodegenerative, cardiovascular and inflammatory diseases. Sirtris researchers are working to translate this research into a potential new class of pharmaceuticals to treat diseases of aging, offering the ability for people to live longer, healthier lives. Sirtris has focused on developing many novel small molecule activators of SIRT1, the most studied member of the sirtuin family. These new chemical entities or NCEs are novel compounds that are chemically unrelated to resveratrol, a naturally occurring compound that was used as an early proof-of-concept for SIRT1 activation. Besides being structurally differentiated from resveratrol, the NCEs are more specific for the target SIRT1 and have improved drug-like properties. The company has completed several early stage translational clinical studies with the first generation NCEs and has several active clinical trials under way. Sirtris operates as an independent Discovery Performance Unit (DPU) within GSK and is located in Technology Square, Cambridge, Mass. Sirtris' culture mixes scientific curiosity with a dynamic, fast-paced environment, resembling its biotech roots while harnessing all of GSK's broad discovery, development, and commercialization capabilities. The company was founded in 2004 and is headquartered in Cambridge, MA.

Arcadian Management Services, Inc. engages in the provision of administrative infrastructure and management services to health care provider groups and hospitals. The company was founded by John H. Austin in 1997 and is headquartered in DE.

Access Closure, Inc. manufactures and distributes medical devices for cardiovascular and peripheral vascular markets. Its products include Mynx ace, Mynx grip, Mynx sealant technology and flash ostial system. The company was in founded in 2002 by Farhad Khosravi and is headquartered in Santa Clara, CA.