Jeff Donofrio

Second Heart Assist, Inc. develops minimally invasive circulatory support platform based on proprietary aortic stent pump technology. The firm's product will be a catheter-based temporary assist pump to treat patients with acute decompensated heart failure and to provide circulatory support to those undergoing percutaneous coronary intervention (PCI). The company was founded by Leslie Miller, Howard J. Leonhardt and Jeff Donofrio in 2015 and is headquartered in Santa Monica, CA.

DentaCell Accelerator is an organization that was converted into an accelerator in 2017 to address innovations in dentistry and support multiple startup launches simultaneously. The company is based in Los Angeles, CA. The company provides access to Leonhardt's Launchpads' building IP estate in stem cell, growth factors, micro pumps, and bioelectric stimulation technologies. The company also offers access to Cal-X Stars Business Accelerator, Inc. network of successful entrepreneurs, investors, mentors, and corporate partners. The company focuses on electroceutical treatment of pseudomonas aeruginosa biofilms. The company was founded in 2014, and the CEO is Howard J. Leonhardt.

KidneyCell is an American company that develops non-invasive bioelectric stimulation for kidney recovery. The company was founded by Howard J. Leonhardt, who has been the CEO since incorporation.

OrthoStim, a company under Leonhardt Ventures LLC, offers a technology platform that utilizes bioelectric stimulation and stem cell-based compositions to promote the body's own healing potential. OrthoStim is based in Irvine, CA, and is led by CEO Howard J. Leonhardt. The company aims to regenerate joints and eliminate joint arthritis pain through bioelectric stimulations and protein expressions for inflammation management, healing, pain relief, and regeneration promotion. OrthoStim's technology platform includes patented customized inflammation management and a proprietary biologics mix that includes bioelectric pre-treated PRF, secretome from amniotic sourcing, selected exosomes, and patent-pending klotho expressing MSCs. The company targets knee, hip, elbow, tendon, cartilage, bone, and muscle indications. However, the products described on the company's website are still in early stage development and are not yet proven safe or effective in statistically significant controlled clinical studies.

TremorStim is a company that specializes in bioelectric signaling to control specific protein expressions or suppressions that help reduce essential tremor movements and duration. The company is based in Irvine, CA, and the CEO of the company is Howard J. Leonhardt. The company offers the TremorStim II treatment protocol, which includes a wrist band, brain band, focused ultrasound, and bodstim exercises. The second-generation system is designed to be miniaturized and wireless, with a comfortable bioelectric watch or glove for the hand/wrist and small bioelectric micro stimulators placed on a patient's upper neck, lower base of the brain, or behind the ears, generally not visible.

AddictiStim provides bioelectric stimulation addiction treatment technology services. The company is based in Irvine, CA. The CEO of the company is Howard J. Leonhardt.

Valvublator is a medical company that rebuilds heart valve leaflets and orifice using a patient's own cells. The company is based in Salt Lake City, UT. The process involves decalcifying, cell sodding, regenerating, surface modifying, and strengthening the heart valve. The company also provides embolitic fragment protection throughout the procedure, ultrasonic cleaning, vacuum removal of debris, and microcurrent regeneration signal that recruits stem cells with homing signal and differentiates them to valve tissue. Valvublator was founded in 1988 by Leslie Miller and Howard J. Leonhardt, and Howard J. Leonhardt has been the CEO since 1988.

InstimCell is an early stage startup that focuses on customized inflammation management with bioelectric stimulation. The American company believes that it can restart a person's chronic inflammation cycle by deriving ideal optimal healing cycles from healthy subjects that have an inflammation-causing event and recover quickly and fully. InstimCell licenses its technology to other startups within Leonhardt's Launchpads accelerators for specific organ applications such as brain injury recovery, pancreas regeneration recovery from pancreatitis, bioelectric cancer treatments, and chronic heart failure recovery. The company was founded by Howard J. Leonhardt, who has been the CEO since incorporation.

BladderCell is a company that focuses on developing a therapy for urinary incontinence. The company is based in Salt Lake City, UT, and the CEO of the company is Howard J. Leonhardt. The company uses bioelectric signals to recruit, proliferate, and differentiate stem cells into bladder muscle, as well as to control the release of proteins for regenerating bladder function. BladderCell's proprietary BC-15 composition includes stem cells, myoblasts, exosomes, matrix, and other support factors that regenerate muscle, urothelium, and restore elasticity.

RegenaLung is an American company founded in 2015 with Richard Koffler as the CEO. The company's focus is on developing innovative solutions for lung diseases using regenerative medicine. RegenaLung's technology involves the use of stem cells to repair damaged lung tissue and improve lung function. The company's mission is to improve the lives of patients suffering from lung diseases by providing effective and safe treatments. RegenaLung is committed to advancing the field of regenerative medicine and bringing new therapies to market.

SkinStim manufactures bioelectric stimulation products. The American company was founded in 2015 by Howard J. Leonhardt. Howard J. Leonhardt has been the CEO since 2015.

Part of Medtronic Plc, World Medical Manufacturing Corp. is a company that makes stents for use in heart surgery. The company is based in Santa Rosa, CA. The company was founded by Howard J. Leonhardt. World Medical Manufacturing was acquired by Arterial Vascular Engineering, Inc., part of Medtronic Plc from January 28, 1999 on December 15, 1998 for $62 million.

Ear-Cell is a company that utilizes bioelectric stimulation to control the release of specific proteins for regenerative purposes. The company is based in Los Angeles, CA and was founded in 2016 by Howard J. Leonhardt. The company has a sequence of proteins that they use for stem cell homing, DNA repair, tissue loosening, increasing elasticity, and promoting wound healing. The company also has special signals to stop tumor cell division and blood supply in cases of ear cancer.

VascuStim is a company that specializes in bioelectric signaling technologies for regeneration, healing, and recovery. The company is based in Santa Monica, CA. The company's focus is on bioelectric and light therapy stimulation. The CEO of the company is Howard J. Leonhardt.

OrthodontiCell, Inc. has developed a revolutionary technology for accelerated tooth movement and stabilization. The company is based in Salt Lake City, UT and was founded by John Marchetto and Howard J. Leonhardt. Over 7 million people worldwide seek orthodontic treatment with braces or aligners to straighten their teeth, which can take up to 18-24 months and result in unwanted side effects and a loss of motivation. OrthodontiCell's proposed clinical protocol gen. ii design driving the science of tooth movement & stabilization is made possible by wearing a bioelectric stimulation mouthpiece only 3 times a week for 20 minutes. The company uses rankl, vegf, and sdf-1 for accelerated tooth movement and opg for stabilization, resulting in a 2/3rds reduction in tooth movement time. Howard J. Leonhardt has been the CEO since incorporation.

HairCell manufactures bioelectric stimulation products for stem cell hairs. The company is based in Los Angeles, CA. The company was founded in 2015. The CEO is Howard J. Leonhardt.

Bio-Leonhardt is an American company that specializes in bioelectric stimulation sequences to reverse fibrosis and convert scar tissue into new beating heart muscle. The company has patented bioelectric signal sequences for stem cell differentiation and follistatin expression, which are key to managing and recovering from advanced heart failure. The company's platform technology components include a bioelectric stimulator, signals and sequences for precise control of regeneration promoting proteins, and a patented stem cell differentiation into heart muscle signal within myocardial scar tissue. The company also has a patent-pending angiogenic bioelectric signal sequence for mature new blood vessel growth and a real-time inflammation reading and management sequence. The company's products are in early stage development and are not yet proven safe or effective in statistically significant controlled clinical studies. The company was founded by Stuart Williams, and the CEO is Howard J. Leonhardt.

Cal X Stars Business Accelerator Inc (Cal X Stars Business Accelerator) is a venture capital subsidiary of Leonhardt Ventures founded in 2012 by Howard J. Leonhardt. The firm is headquartered in Playa Vista, California.